Ontology highlight
ABSTRACT:
SUBMITTER: Garcin ED
PROVIDER: S-EPMC2868503 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Garcin Elsa D ED Arvai Andrew S AS Rosenfeld Robin J RJ Kroeger Matt D MD Crane Brian R BR Andersson Gunilla G Andrews Glen G Hamley Peter J PJ Mallinder Philip R PR Nicholls David J DJ St-Gallay Stephen A SA Tinker Alan C AC Gensmantel Nigel P NP Mete Antonio A Cheshire David R DR Connolly Stephen S Stuehr Dennis J DJ Aberg Anders A Wallace Alan V AV Tainer John A JA Getzoff Elizabeth D ED
Nature chemical biology 20081012 11
Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations. The high active site conservation among all three NOS isozymes hinders the design of selective NOS inhibitors to treat inflammation, arthritis, stroke, septic shock and cancer. Our crystal structures and mutagenesis results identified an isozyme-specific induced-fit binding mode linking a cascade of conformational ...[more]