Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5287043 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Li Huiying H Wang Heng-Yen HY Kang Soosung S Silverman Richard B RB Poulos Thomas L TL
Biochemistry 20160616 26
Development of potent and isoform selective nitric oxide synthase (NOS) inhibitors is challenging because of the structural similarity in the heme active sites. One amino acid difference between NOS isoforms, Asp597 in rat neuronal NOS (nNOS) versus Asn368 in bovine endothelial NOS (eNOS), has been identified as the structural basis for why some dipeptide amide inhibitors bind more tightly to nNOS than to eNOS. We now have found that the same amino acid variation is responsible for substantially ...[more]