Ontology highlight
ABSTRACT:
SUBMITTER: Yoon CH
PROVIDER: S-EPMC2868534 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Yoon Cheol-Hee CH Miah Mohammad Alam MA Kim Kwang Pyo KP Bae Yong-Soo YS
EMBO reports 20100416 5
Cell division cycle 2 (Cdc2) protein is an essential subunit of M-phase kinase (MPK), which has a key role in G2/M transition. Even though the control of MPK activity has been well established with regard to the phosphorylation of Cdc2 at Thr 14 and/or Tyr 15 and Thr 161, little is known about the proteolytic control of Cdc2. In this study, we observed that Cdc2 was downregulated under genotoxic stresses and that double-stranded RNA-activated protein kinase (PKR) was involved in the process. The ...[more]