Ontology highlight
ABSTRACT:
SUBMITTER: Ma YC
PROVIDER: S-EPMC4721529 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Ma Yong-Cheng YC Su Nan N Shi Xiao-Jing XJ Zhao Wen W Ke Yu Y Zi Xiaolin X Zhao Ning-Min NM Qin Yu-Hua YH Zhao Hong-Wei HW Liu Hong-Min HM
Toxicology and applied pharmacology 20141120 2
Jaridonin, a novel diterpenoid from Isodon rubescens, has been shown previously to inhibit proliferation of esophageal squamous cancer cells (ESCC) through G2/M phase cell cycle arrest. However, the involved mechanism is not fully understood. In this study, we found that the cell cycle arrest by Jaridonin was associated with the increased expression of phosphorylation of ATM at Ser1981 and Cdc2 at Tyr15. Jaridonin also resulted in enhanced phosphorylation of Cdc25C via the activation of checkpoi ...[more]