MicroRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay.
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ABSTRACT:
SUBMITTER: Choe J
PROVIDER: S-EPMC2868547 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay.
Choe Junho J Cho Hana H Lee Hyung Chul HC Kim Yoon Ki YK
EMBO reports 20100416 5
Imperfect base-pairing between microRNA (miRNA) and the 3'-untranslated region of target messenger RNA (mRNA) triggers translational repression of the target mRNA. Here, we provide evidence that human Argonaute 2 targets cap-binding protein (CBP)80/20-bound mRNAs and exon junction complex-bound mRNAs and inhibits nonsense-mediated mRNA decay (NMD), which is restricted tightly to CBP80/20-bound mRNAs. Furthermore, microarray analyses reveal that a subset of cellular transcripts, which are expecte ...[more]
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