Cotranslational microRNA mediated messenger RNA destabilization.
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ABSTRACT:
SUBMITTER: Tat TT
PROVIDER: S-EPMC4859803 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Cotranslational microRNA mediated messenger RNA destabilization.
Tat Trinh To TT Maroney Patricia A PA Chamnongpol Sangpen S Coller Jeff J Nilsen Timothy W TW
eLife 20160408
MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those mRNAs. Considerable evidence indicates that miRNAs destabilize targeted mRNAs by recruiting enzymes that function in normal mRNA decay and mRNA degradation is widely thought to occur when mRNAs are in a ribosome free state. Nevertheless, when examine ...[more]
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