Ontology highlight
ABSTRACT:
SUBMITTER: Widen E
PROVIDER: S-EPMC2869010 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Widén Elisabeth E Ripatti Samuli S Cousminer Diana L DL Surakka Ida I Lappalainen Tuuli T Järvelin Marjo-Riitta MR Eriksson Johan G JG Raitakari Olli O Salomaa Veikko V Sovio Ulla U Hartikainen Anna-Liisa AL Pouta Anneli A McCarthy Mark I MI Osmond Clive C Kajantie Eero E Lehtimäki Terho T Viikari Jorma J Kähönen Mika M Tyler-Smith Chris C Freimer Nelson N Hirschhorn Joel N JN Peltonen Leena L Palotie Aarno A
American journal of human genetics 20100415 5
We have studied the largely unknown genetic underpinnings of height growth by using a unique resource of longitudinal childhood height data available in Finnish population cohorts. After applying GWAS mapping of potential genes influencing pubertal height growth followed by further characterization of the genetic effects on complete postnatal growth trajectories, we have identified strong association between variants near LIN28B and pubertal growth (rs7759938; female p = 4.0 x 10(-9), male p = 1 ...[more]