Ontology highlight
ABSTRACT:
SUBMITTER: Gong LW
PROVIDER: S-EPMC2871335 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Gong Liang-Wei LW de Toledo Guillermo Alvarez GA Lindau Manfred M
Nature cell biology 20070722 8
Release of charged neurotransmitter molecules through a narrow fusion pore requires charge compensation by other ions. It has been proposed that this may occur by ion flow from the cytosol through channels in the vesicle membrane, which would generate a net outward current. This hypothesis was tested in chromaffin cells using cell-attached patch amperometry that simultaneously measured catecholamine release from single vesicles and ionic current across the patch membrane. No detectable current w ...[more]