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Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives.

ABSTRACT: The growing awareness of the importance of chirality in conjunction with biological activity has led to an increasing demand for efficient methods for the industrial synthesis of enantiomerically pure compounds. Polyhydroxyalkanotes (PHAs) are a family of polyesters consisting of over 140 chiral R-hydroxycarboxylic acids (R-HAs), representing a promising source for obtaining chiral chemicals from renewable carbon sources. Although some R-HAs have been produced for some time and certain knowledge of the production processes has been gained, large-scale production has not yet been possible. In this article, through analysis of the current advances in production of these acids, we present guidelines for future developments in biotechnological processes for R-HA production.

SUBMITTER: Ren Q

PROVIDER: S-EPMC2872024 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives.

Ren Qun Q Ruth Katinka K Thöny-Meyer Linda L Zinn Manfred M

Applied microbiology and biotechnology 20100601 1

The growing awareness of the importance of chirality in conjunction with biological activity has led to an increasing demand for efficient methods for the industrial synthesis of enantiomerically pure compounds. Polyhydroxyalkanotes (PHAs) are a family of polyesters consisting of over 140 chiral R-hydroxycarboxylic acids (R-HAs), representing a promising source for obtaining chiral chemicals from renewable carbon sources. Although some R-HAs have been produced for some time and certain knowledge ...[more]

PMID: 20393709

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Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives.

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Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives.

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