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Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.

ABSTRACT: The advent of immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4) has resulted in unprecedented long-term remissions of unresectable cancers. The efficacy of checkpoint inhibitors was recently demonstrated in gastrointestinal malignancies with mismatch repair deficiencies (dMMR). Pembrolizumab became the first tissue-agnostic US FDA-approved drug based on the presence of the predictive biomarker dMMR. In addition, the FDA in 2017 approved pembrolizumab for PD-L1-positive advanced gastric cancer in third-line and second-line hepatocellular therapy. Novel treatment strategies such as using anti-carcinoembryonic antigen (CEA) bispecific T cells have led to remarkable responses in microsatellite instability-low colorectal cancer. Other major breakthroughs in treating upper gastrointestinal malignancies in 2017 are discussed.

SUBMITTER: Solomon BL

PROVIDER: S-EPMC5925434 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.

Solomon Benjamin L BL Garrido-Laguna Ignacio I

Future oncology (London, England) 20180315 10

The advent of immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4) has resulted in unprecedented long-term remissions of unresectable cancers. The efficacy of checkpoint inhibitors was recently demonstrated in gastrointestinal malignancies with mismatch repair deficiencies (dMMR). Pembrolizumab became the first tissue-agnostic US FDA-approved drug based on the presence of the predictive biomarker dMMR. In addition, the FDA in 2017 approved pembrolizumab for PD-L1-positive advanced gastric cance ...[more]

PMID: 29542354

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Dataset Information

Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.

Publications

Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.

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