Ontology highlight
ABSTRACT:
SUBMITTER: Xie H
PROVIDER: S-EPMC2872440 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Xie Hehuang H Wang Min M Bonaldo Maria de F Mde F Rajaram Veena V Stellpflug Wendy W Smith Christina C Arndt Kelly K Goldman Stewart S Tomita Tadanori T Soares Marcelo B MB
Proceedings of the National Academy of Sciences of the United States of America 20100329 15
Global loss of DNA methylation has been known for decades as an epigenomic aberration associated with carcinogenesis and cancer progression. Loss of DNA methylation affects predominantly repetitive elements, which encompass >50% of the CpG dinucleotides present in the human genome. Because of the lack of an effective approach, no studies have been conducted to reveal such genome-wide methylation changes at a single-base resolution. To precisely determine the CpG sites with methylation loss durin ...[more]