Ontology highlight
ABSTRACT:
SUBMITTER: Lobachev KS
PROVIDER: S-EPMC313988 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
Lobachev K S KS Stenger J E JE Kozyreva O G OG Jurka J J Gordenin D A DA Resnick M A MA
The EMBO journal 20000701 14
The nearly one million ALU: repeats in human chromosomes are a potential threat to genome integrity. ALU:s form dense clusters where they frequently appear as inverted repeats, a sequence motif known to cause DNA rearrangements in model organisms. Using a yeast recombination system, we found that inverted ALU: pairs can be strong initiators of genetic instability. The highly recombinagenic potential of inverted ALU: pairs was dependent on the distance between the repeats and the level of sequenc ...[more]