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Rapid access to morphinones: removal of 4, 5-ether bridge with Pd-catalyzed triflate reduction.

ABSTRACT: A new synthetic method for the removal of the 4, 5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.

SUBMITTER: Hupp CD

PROVIDER: S-EPMC2872489 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Rapid access to morphinones: removal of 4, 5-ether bridge with Pd-catalyzed triflate reduction.

Hupp Christopher D CD Neumeyer John L JL

Tetrahedron letters 20100401 17

A new synthetic method for the removal of the 4, 5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety. ...[more]

PMID: 20495617

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