Ontology highlight
ABSTRACT:
SUBMITTER: Alexy EJ
PROVIDER: S-EPMC5632216 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Alexy Eric J EJ Virgil Scott C SC Bartberger Michael D MD Stoltz Brian M BM
Organic letters 20170913 19
A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The α-quaternary 4-thiopyranones produced are challenging to access by standard enolate alkylation owing to facile ring-opening β-sulfur elimination. In addition, reduction of the carbon-sulfur bonds provides access to elusive acyclic α-quaternary ketones. The alkylated products are obtained in up to 92% yield and 94% enantiomeric excess. ...[more]