White matter diffusion alterations in normal women at risk of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Smith CD
PROVIDER: S-EPMC2873054 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
White matter diffusion alterations in normal women at risk of Alzheimer's disease.
Smith Charles D CD Chebrolu Himachandra H Andersen Anders H AH Powell David A DA Lovell Mark A MA Xiong Shuling S Gold Brian T BT
Neurobiology of aging 20080917 7
Increased white matter mean diffusivity and decreased fractional anisotropy (FA) has been observed in subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). We sought to determine whether similar alterations of white matter occur in normal individuals at risk of AD. Diffusion tensor images were acquired in 42 cognitively normal right-handed women with both a family history of dementia and at least one apolipoprotein E4 allele. These were compared with images from 2 ...[more]
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