Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains.
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ABSTRACT:
SUBMITTER: Swarts BM
PROVIDER: S-EPMC2873617 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains.
Swarts Benjamin M BM Guo Zhongwu Z
Journal of the American Chemical Society 20100501 19
A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure. ...[more]
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