Ontology highlight
ABSTRACT:
SUBMITTER: Burgula S
PROVIDER: S-EPMC3312375 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Burgula Srinivas S Swarts Benjamin M BM Guo Zhongwu Z
Chemistry (Weinheim an der Bergstrasse, Germany) 20111221 4
The first total synthesis of a glycosylphosphatidylinositol (GPI) anchor bearing a polyunsaturated arachidonoyl fatty acid is reported. This lipid is found in mammalian GPIs that do not undergo lipid remodeling, a process that has important implications in the localization and function of GPI-anchored proteins. Incorporation of the oxidation- and reduction-sensitive arachidonoyl lipid in the target GPI was accomplished by using the para-methoxybenzyl (PMB) group for permanent hydroxyl group prot ...[more]