Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC2873971 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Zhang Bin B Strauss Adam C AC Chu Su S Li Min M Ho Yinwei Y Shiang Keh-Dong KD Snyder David S DS Huettner Claudia S CS Shultz Leonard L Holyoake Tessa T Bhatia Ravi R
Cancer cell 20100501 5
Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse. Here we investigated the ability of HDAC inhibitors (HDACis) to target CML stem cells. Treatment with HDACis combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo administrati ...[more]