Ontology highlight
ABSTRACT:
SUBMITTER: Good-Jacobson KL
PROVIDER: S-EPMC2874069 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Good-Jacobson Kim L KL Szumilas Courtney G CG Chen Lieping L Sharpe Arlene H AH Tomayko Mary M MM Shlomchik Mark J MJ
Nature immunology 20100509 6
Memory B and plasma cells (PCs) are generated in the germinal center (GC). Because follicular helper T cells (T(FH) cells) have high expression of the immunoinhibitory receptor PD-1, we investigated the role of PD-1 signaling in the humoral response. We found that the PD-1 ligands PD-L1 and PD-L2 were upregulated on GC B cells. Mice deficient in PD-L2 (Pdcd1lg2(-/-)), PD-L1 and PD-L2 (Cd274(-/-)Pdcd1lg2(-/-)) or PD-1 (Pdcd1(-/-)) had fewer long-lived PCs. The mechanism involved more GC cell deat ...[more]