Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC5940267 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chen Chao C Zhai Sulan S Zhang Le L Chen Jingjing J Long Xuehui X Qin Jun J Li Jianhua J Huo Ran R Wang Xiaoming X
The Journal of experimental medicine 20180404 5
The production of high-affinity antibody is essential for pathogen clearance. Antibody affinity is increased through germinal center (GC) affinity maturation, which relies on BCR somatic hypermutation (SHM) followed by antigen-based selection. GC B cell proliferation is essentially involved in these processes; it provides enough templates for SHM and also serves as a critical mechanism of positive selection. In this study, we show that expression of epigenetic regulator ubiquitin-like with PHD a ...[more]