Ontology highlight
ABSTRACT:
SUBMITTER: Saccone NL
PROVIDER: S-EPMC2874321 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Saccone Nancy L NL Wang Jen C JC Breslau Naomi N Johnson Eric O EO Hatsukami Dorothy D Saccone Scott F SF Grucza Richard A RA Sun Lingwei L Duan Weimin W Budde John J Culverhouse Robert C RC Fox Louis L Hinrichs Anthony L AL Steinbach Joseph Henry JH Wu Meng M Rice John P JP Goate Alison M AM Bierut Laura J LJ
Cancer research 20090825 17
Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of European descent. We have carried out a detailed study of this region using dense genotyping in both European-Americans and African-Americans. We genotyped 75 known single nucleotide polymorphisms (SNPs) and one sequencing-discovered SNP in an Afric ...[more]