Ontology highlight
ABSTRACT:
SUBMITTER: Zaynagetdinov R
PROVIDER: S-EPMC2874442 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Zaynagetdinov Rinat R Ryzhov Sergey S Goldstein Anna E AE Yin Huiyong H Novitskiy Sergey V SV Goleniewska Kasia K Polosukhin Vasiliy V VV Newcomb Dawn C DC Mitchell Daphne D Morschl Eva E Zhou Yang Y Blackburn Michael R MR Peebles R Stokes RS Biaggioni Italo I Feoktistov Igor I
American journal of respiratory cell and molecular biology 20090625 5
Pharmacologic evidence suggests that activation of A(2B) adenosine receptors results in proinflammatory effects relevant to the progression of asthma, a chronic lung disease associated with elevated interstitial adenosine concentrations in the lung. This concept has been challenged by the finding that genetic removal of A(2B) receptors leads to exaggerated responses in models of acute inflammation. Therefore, the goal of our study was to determine the effects of A(2B) receptor gene ablation in t ...[more]