Ontology highlight
ABSTRACT:
SUBMITTER: Murakami Y
PROVIDER: S-EPMC2874541 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Murakami Yuichi Y Tanimoto Kazushi K Fujiwara Hiroshi H An Jun J Suemori Koichiro K Ochi Toshiki T Hasegawa Hitoshi H Yasukawa Masaki M
Virology journal 20100510
Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased ...[more]