Ontology highlight
ABSTRACT:
SUBMITTER: Beeghly-Fadiel A
PROVIDER: S-EPMC2874636 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Beeghly-Fadiel Alicia A Lu Wei W Gao Yu-Tang YT Long Jirong J Deming Sandra L SL Cai Qiuyin Q Zheng Ying Y Shu Xiao-ou XO Zheng Wei W
Breast cancer research and treatment 20091016 2
The epithelial transmembrane glycoprotein E-cadherin (CDH1) is necessary for intercellular adhesion, cell signaling, and maintenance of cellular differentiation; reduced expression contributes to cell proliferation, invasion, and cancer progression. Functional or potentially functional single nucleotide polymorphisms (SNPs) in E-cadherin have been previously identified and evaluated in relation to cancer risk; however, studies on breast cancer have been sparse. Forty-six SNPs were genotyped to c ...[more]