Ontology highlight
ABSTRACT:
SUBMITTER: Jiang JK
PROVIDER: S-EPMC2874658 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Jiang Jian-kang JK Boxer Matthew B MB Vander Heiden Matthew G MG Shen Min M Skoumbourdis Amanda P AP Southall Noel N Veith Henrike H Leister William W Austin Christopher P CP Park Hee Won HW Inglese James J Cantley Lewis C LC Auld Douglas S DS Thomas Craig J CJ
Bioorganic & medicinal chemistry letters 20100411 11
Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells. Here, we describe activators of PKM2 based upon a substituted thieno[3,2-b]pyrrole[3,2-d]pyridazinone scaffold. The synthesis of these agents, structure-activity relationships, analys ...[more]