Ontology highlight
ABSTRACT:
SUBMITTER: Boxer MB
PROVIDER: S-EPMC2818804 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Boxer Matthew B MB Jiang Jian-kang JK Vander Heiden Matthew G MG Shen Min M Skoumbourdis Amanda P AP Southall Noel N Veith Henrike H Leister William W Austin Christopher P CP Park Hee Won HW Inglese James J Cantley Lewis C LC Auld Douglas S DS Thomas Craig J CJ
Journal of medicinal chemistry 20100201 3
The metabolism of cancer cells is altered to support rapid proliferation. Pharmacological activators of a tumor cell specific pyruvate kinase isozyme (PKM2) may be an approach for altering the classic Warburg effect characteristic of aberrant metabolism in cancer cells yielding a novel antiproliferation strategy. In this manuscript, we detail the discovery of a series of substituted N,N'-diarylsulfonamides as activators of PKM2. The synthesis of numerous analogues and the evaluation of structure ...[more]