Unknown

Dataset Information

0

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures.


ABSTRACT: Since the beginning of the highly active antiretroviral therapy (HAART) era, epidemiological evidence indicates an increasing incidence of Alzheimer's (AD)-like brain pathology in aging HIV patients. Emerging evidence warns of potential convergent mechanisms underlying HIV- and Abeta-mediated neurodegeneration. We found that HIV-1 Tat B and gp120 promote the secretion of Abeta 1-42 in primary rat fetal hippocampal cell cultures. Our results demonstrate that the variant of Tat expressed by the neurotropic subtype of HIV-1 virus (HIV-1 clade B) specifically induces both the release of amyloidogenic Abeta 1-42 and the accumulation of cell-bound amyloid aggregates. The results of the research rationalize testing of the ability of beta-amyloid aggregation inhibitors to attenuate HIV protein-mediated cognitive deficits in animal models of NeuroAIDS. The long-term goal of the study is to evaluate the potential benefits of anti-amyloidogenic therapies for management of cognitive dysfunction in aging HIV-1 patients.

SUBMITTER: Aksenov MY 

PROVIDER: S-EPMC2874942 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures.

Aksenov M Y MY   Aksenova M V MV   Mactutus C F CF   Booze R M RM  

Neuroscience letters 20100402 3


Since the beginning of the highly active antiretroviral therapy (HAART) era, epidemiological evidence indicates an increasing incidence of Alzheimer's (AD)-like brain pathology in aging HIV patients. Emerging evidence warns of potential convergent mechanisms underlying HIV- and Abeta-mediated neurodegeneration. We found that HIV-1 Tat B and gp120 promote the secretion of Abeta 1-42 in primary rat fetal hippocampal cell cultures. Our results demonstrate that the variant of Tat expressed by the ne  ...[more]

Similar Datasets

| S-EPMC2770879 | biostudies-literature
| S-EPMC8928815 | biostudies-literature
| S-EPMC2480665 | biostudies-literature
| S-EPMC3871014 | biostudies-literature
| S-EPMC5338800 | biostudies-literature
| S-EPMC3634196 | biostudies-literature
| S-EPMC5654847 | biostudies-literature
2008-11-12 | GSE12483 | GEO
| S-EPMC3745260 | biostudies-literature
| S-EPMC2943025 | biostudies-literature