Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures.
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ABSTRACT:
SUBMITTER: Aksenov MY
PROVIDER: S-EPMC2770879 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures.
Aksenov Michael Y MY Aksenova Marina V MV Mactutus Charles F CF Booze Rosemarie M RM
Experimental neurology 20090715 2
This study reports that the cysteine 22-->glycine 22 substitution in the HIV-1 Tat 1-86 B significantly attenuates its neurotoxicity. Consistent with previous studies, direct interactions of rat hippocampal cells with Tat 1-86 B were shown to cause dose-dependent and time-dependent neurotoxicity associated with activation of caspases from the mitochondrial apoptotic pathway. Despite the similar binding/uptake properties, Cys22 Tat 1-86 B failed to induce significant neurotoxicity and activation ...[more]
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