Ontology highlight
ABSTRACT:
SUBMITTER: Santi CM
PROVIDER: S-EPMC2875124 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Santi Celia M CM Martínez-López Pablo P de la Vega-Beltrán José Luis JL Butler Alice A Alisio Arturo A Darszon Alberto A Salkoff Lawrence L
FEBS letters 20100209 5
Here we show a unique example of male infertility conferred by a gene knockout of the sperm-specific, pH-dependent SLO3 potassium channel. In striking contrast to wild-type sperm which undergo membrane hyperpolarization during capacitation, we found that SLO3 mutant sperm undergo membrane depolarization. Several defects in SLO3 mutant sperm are evident under capacitating conditions, including impaired motility, a bent "hairpin" shape, and failure to undergo the acrosome reaction (AR). The failur ...[more]