Ontology highlight
ABSTRACT:
SUBMITTER: Vicens A
PROVIDER: S-EPMC5337896 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Vicens Alberto A Andrade-López Karla K Cortez Diego D Gutiérrez Rosa María RM Treviño Claudia L CL
FEBS open bio 20170217 3
Slo3 is a sperm-specific potassium (K<sup>+</sup>) channel essential for male fertility. Slo3 channels have so far been considered to be specific to mammals. Through exploratory genomics, we identified the <i>Slo3</i> gene in the genome of terrestrial (birds and reptiles) and aquatic (fish) vertebrates. In the case of fish, <i>Slo3</i> has undergone several episodes of gene loss. Transcriptomic analysis showed that vertebrate Slo3 transcript orthologues are predominantly expressed in testis, in ...[more]