Ontology highlight
ABSTRACT:
SUBMITTER: Aghamohammadzadeh S
PROVIDER: S-EPMC2875176 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Aghamohammadzadeh Soheil S Ayscough Kathryn R KR
Nature cell biology 20090713 8
Key features of clathrin-mediated endocytosis have been conserved across evolution. However, endocytosis in Saccharomyces cerevisiae is completely dependent on a functional actin cytoskeleton, whereas actin appears to be less critical in mammalian cell endocytosis. We reveal that the fundamental requirement for actin in the early stages of yeast endocytosis is to provide a strong framework to support the force generation needed to direct the invaginating plasma membrane into the cell against tur ...[more]