Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.
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ABSTRACT:
SUBMITTER: Frid A
PROVIDER: S-EPMC2875440 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.
Frid Anders A Sterner Gunnar N GN Löndahl Magnus M Wiklander Clara C Cato Anne A Vinge Ellen E Andersson Anders A
Diabetes care 20100309 6
<h4>Objective</h4>To study trough levels of metformin in serum and its intra-individual variation in patients using a newly developed assay.<h4>Research design and methods</h4>Trough serum levels of metformin were measured once using liquid chromatography-tandem mass spectrometry (LCMSMS) in 137 type 2 diabetic patients with varying renal function (99 men) and followed repeatedly during 2 months in 20 patients (16 men) with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2) body su ...[more]
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