Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2.
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SUBMITTER: Bentsi-Barnes IK
PROVIDER: S-EPMC2876195 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2.
Bentsi-Barnes Ikuko K IK Kuo Fang-Ting FT Barlow Gillian M GM Pisarska Margareta D MD
Fertility and sterility 20091114 1
FOXL2 is expressed in granulosa cells (GC) of small and medium ovarian follicles, functions as a repressor of the human steroidogenic acute regulatory gene, a marker of a GC differentiation, and its mutation is associated with premature ovarian failure (POF) in women with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), type I. We now report that FOXL2 also represses the transcription of aromatase, P450scc, and cyclin D2, three other key genes involved in GC proliferation, differenti ...[more]
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