Ontology highlight
ABSTRACT:
SUBMITTER: Yamak A
PROVIDER: S-EPMC3910654 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Yamak Abir A Latinkic Branko V BV Dali Rola R Temsah Rana R Nemer Mona M
Proceedings of the National Academy of Sciences of the United States of America 20140113 4
The G1 cyclins play a pivotal role in regulation of cell differentiation and proliferation. The mechanisms underlying their cell-specific roles are incompletely understood. Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of transcription factor GATA4, a key regulator of cardiomyocyte growth and differentiation. GATA4 recruits CycD2 to its target promoters, and their interaction results in synergistic activation of GATA-dependent transcription. This effect is specific to ...[more]