Ontology highlight
ABSTRACT:
SUBMITTER: Grandl J
PROVIDER: S-EPMC2876202 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Nature neuroscience 20100422 6
TRPV1 is the founding and best-studied member of the family of temperature-activated transient receptor potential ion channels (thermoTRPs). Voltage, chemicals and heat allosterically gate TRPV1. Molecular determinants of TRPV1 activation by capsaicin, allicin, acid, ammonia and voltage have been identified. However, the structures and mechanisms mediating TRPV1's pronounced temperature sensitivity remain unclear. Recent studies of the related channel TRPV3 identified residues in the pore region ...[more]