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Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates.

ABSTRACT: Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation.

SUBMITTER: Burns KE

PROVIDER: S-EPMC2876485 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates.

Burns Kristin E KE Pearce Michael J MJ Darwin K Heran KH

Journal of bacteriology 20100316 11

Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation. ...[more]

PMID: 20233925

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