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Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

ABSTRACT: Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow (

SUBMITTER: Julg B 

PROVIDER: S-EPMC2876607 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

Julg B B   Williams K L KL   Reddy S S   Bishop K K   Qi Y Y   Carrington M M   Goulder P J PJ   Ndung'u T T   Walker B D BD  

Journal of virology 20100324 11

Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13)  ...[more]

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