Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
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ABSTRACT:
SUBMITTER: Julg B
PROVIDER: S-EPMC2876607 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
Julg B B Williams K L KL Reddy S S Bishop K K Qi Y Y Carrington M M Goulder P J PJ Ndung'u T T Walker B D BD
Journal of virology 20100324 11
Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) ...[more]
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