Nevirapine inhibits the anti-HIV activity of CD8+ cells.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC3653990 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Nevirapine inhibits the anti-HIV activity of CD8+ cells.
Liu Lianxing L Wang Lin L Huang Liusheng L Siu Vincent V Teque Fernando F Aweeka Francesca T FT Levy Jay A JA
Journal of acquired immune deficiency syndromes (1999) 20130601 2
Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidov ...[more]
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