Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai A
PROVIDER: S-EPMC2876686 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20100412 12
Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through a single-pass transmembrane receptor, plexin D1, to provide a repulsive cue for plexin D1-expressing endothelial cells, thus providing a highly conserved and developmentally regulated signaling system guiding the growth of blood vessels. We show here that Sema3E acts as a potent inhibitor of adult and tumor-induced angiogenesis. Activation of plexin D1 by Sema3E causes the rapid disassembly of integrin-medi ...[more]