Ontology highlight
ABSTRACT:
SUBMITTER: Obeid S
PROVIDER: S-EPMC2876968 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Obeid Samra S Blatter Nina N Kranaster Ramon R Schnur Andreas A Diederichs Kay K Welte Wolfram W Marx Andreas A
The EMBO journal 20100416 10
Abasic sites represent the most frequent DNA lesions in the genome that have high mutagenic potential and lead to mutations commonly found in human cancers. Although these lesions are devoid of the genetic information, adenine is most efficiently inserted when abasic sites are bypassed by DNA polymerases, a phenomenon termed A-rule. In this study, we present X-ray structures of a DNA polymerase caught while incorporating a nucleotide opposite an abasic site. We found that a functionally importan ...[more]