Ontology highlight
ABSTRACT:
SUBMITTER: Nair DT
PROVIDER: S-EPMC3127253 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Nair Deepak T DT Johnson Robert E RE Prakash Louise L Prakash Satya S Aggarwal Aneel K AK
Journal of molecular biology 20101215 1
Abasic (apurinic/apyrimidinic) sites are among the most abundant DNA lesions in humans, and they present a strong block to replication. They are also highly mutagenic because when replicative DNA polymerases manage to insert a nucleotide opposite the lesion, they prefer to insert an A. Rev1, a member of Y-family DNA polymerases, does not obey the A-rule. This enzyme inserts a C opposite an abasic lesion with much greater catalytic efficiency than an A, G, or T. We present here the structure of y ...[more]