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Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3.

ABSTRACT: An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

SUBMITTER: Wang Q

PROVIDER: S-EPMC2877631 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3.

Wang Qianli Q Xue Jie J Guo Zhongwu Z

Chemical communications (Cambridge, England) 20090827 37

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented. ...[more]

PMID: 19753348

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