Ontology highlight
ABSTRACT:
SUBMITTER: Lankas F
PROVIDER: S-EPMC2879501 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lankas F F Spacková N N Moakher M M Enkhbayar P P Sponer J J
Nucleic acids research 20100131 10
A method is proposed to measure global bending in DNA and RNA structures. It relies on a properly defined averaging of base-fixed coordinate frames, computes mean frames of suitably chosen groups of bases and uses these mean frames to evaluate bending. The method is applied to DNA A-tracts, known to induce considerable bend to the double helix. We performed atomistic molecular dynamics simulations of sequences containing the A(4)T(4) and T(4)A(4) tracts, in a single copy and in two copies phased ...[more]