Ontology highlight
ABSTRACT:
SUBMITTER: Swinger KK
PROVIDER: S-EPMC165621 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Swinger Kerren K KK Lemberg Kathryn M KM Zhang Ying Y Rice Phoebe A PA
The EMBO journal 20030701 14
HU and IHF are members of a family of prokaryotic proteins that interact with the DNA minor groove in a sequence-specific (IHF) or non-specific (HU) manner to induce and/or stabilize DNA bending. HU plays architectural roles in replication initiation, transcription regulation and site-specific recombination, and is associated with bacterial nucleoids. Cocrystal structures of Anabaena HU bound to DNA (1P71, 1P78, 1P51) reveal that while underlying proline intercalation and asymmetric charge neutr ...[more]