Ontology highlight
ABSTRACT:
SUBMITTER: Apsel B
PROVIDER: S-EPMC2880455 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Apsel Beth B Blair Jimmy A JA Gonzalez Beatriz B Nazif Tamim M TM Feldman Morri E ME Aizenstein Brian B Hoffman Randy R Williams Roger L RL Shokat Kevan M KM Knight Zachary A ZA
Nature chemical biology 20081012 11
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we report the systematic discovery of molecules that potently inhibit both tyrosine kinases and phosphatidylinositol-3-OH kinases, two protein families that are among the most intensely pursued cancer dru ...[more]