Ontology highlight
ABSTRACT:
SUBMITTER: Smith AB
PROVIDER: S-EPMC2880660 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Organic letters 20090301 5
An efficient, second-generation synthesis of the signature dioxabicyclo[3.2.1]octane core of (+)-sorangicin A (1), in conjunction with an effective, stereocontrolled protocol to arrive at the requisite (Z,Z,E)-triene acid system has been developed. Highlights of the core construction entail a three-component union, a KHMDS-promoted epoxide ring formation-ring opening cascade, a Takai olefination, and a chemoselective Sharpless dihydroxylation. Assembly of the triene acid system was then achieved ...[more]