Ontology highlight
ABSTRACT:
SUBMITTER: Sikdar N
PROVIDER: S-EPMC2880862 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Sikdar Nilabja N Banerjee Soma S Lee Kyoo-young KY Wincovitch Stephen S Pak Evgenia E Nakanishi Koji K Jasin Maria M Dutra Amalia A Myung Kyungjae K
Cell cycle (Georgetown, Tex.) 20091007 19
Genomic integrity depends on DNA replication, recombination and repair, particularly in S phase. We demonstrate that a human homologue of yeast Elg1 plays an important role in S phase to preserve genomic stability. The level of ELG1 is induced during recovery from a variety of DNA damage. In response to DNA damage, ELG1 forms distinct foci at stalled DNA replication forks that are different from DNA double strand break foci. Targeted gene knockdown of ELG1 resulted in spontaneous foci formation ...[more]