HangOut: generating clean PSI-BLAST profiles for domains with long insertions.
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ABSTRACT:
SUBMITTER: Kim BH
PROVIDER: S-EPMC2881392 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
HangOut: generating clean PSI-BLAST profiles for domains with long insertions.
Kim Bong-Hyun BH Cong Qian Q Grishin Nick V NV
Bioinformatics (Oxford, England) 20100422 12
<h4>Unlabelled</h4>Profile-based similarity search is an essential step in structure-function studies of proteins. However, inclusion of non-homologous sequence segments into a profile causes its corruption and results in false positives. Profile corruption is common in multidomain proteins, and single domains with long insertions are a significant source of errors. We developed a procedure (HangOut) that, for a single domain with specified insertion position, cleans erroneously extended PSI-BLA ...[more]
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