Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC2881737 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Xu Xiang X Vatsyayan Jaya J Gao Chenxi C Bakkenist Christopher J CJ Hu Jing J
The Journal of biological chemistry 20100426 24
Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deacetylase activity. By stimulating eIF4E sumoylation, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and induces the protein synthesis of a subset of eIF4E-resp ...[more]