Ontology highlight
ABSTRACT:
SUBMITTER: Gnanasundram SV
PROVIDER: S-EPMC5727396 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Gnanasundram Sivakumar Vadivel SV Pyndiah Slovénie S Daskalogianni Chrysoula C Armfield Kate K Nylander Karin K Wilson Joanna B JB Fåhraeus Robin R
Nature communications 20171213 1
The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not known. We here show that mRNA translation stress in cis triggered by the gly-ala repeat sequence of Epstein-Barr virus (EBV)-encoded EBNA1, results in PI3Kδ-dependent induction of E2F1 mRNA translation with the consequent activation of c-Myc and cell ...[more]